Medcalf R L, Kuhn R J, Iwanov V, Mathews J D, Moulds R F
Clin Exp Pharmacol Physiol. 1983 May-Jun;10(3):369-73. doi: 10.1111/j.1440-1681.1983.tb00215.x.
Circulating immune complexes in excess of the equivalent of 20 micrograms/ml heat-aggregated IgG were found in fourteen out of twenty patients diagnosed as having preeclampsia. Only six of the nineteen controls tested had similar levels of immune complexes. Recent studies have established that concentrations of heat aggregated IgG in excess of 20 micrograms/ml activate human platelets to release sufficient concentrations of vasoactive agents to constrict a human blood vessel in vitro. It is therefore suggested that in vivo platelet activation by circulating immune complexes may release sufficient concentrations of vasoactive agents to contribute to the hypertension in pre-eclampsia.
在被诊断为先兆子痫的20名患者中，有14名患者的循环免疫复合物超过相当于20微克/毫升热聚集免疫球蛋白G的水平。在接受检测的19名对照者中，只有6名具有类似水平的免疫复合物。最近的研究证实，超过20微克/毫升的热聚集免疫球蛋白G浓度可激活人体血小板，从而释放出足够浓度的血管活性物质，以便在体外使人体血管收缩。因此有人提出，循环免疫复合物在体内激活血小板可能会释放出足够浓度的血管活性物质，从而导致先兆子痫患者出现高血压。
