Maraud R, Audine M, Stoll R
Gen Comp Endocrinol. 1983 Sep;51(3):329-37. doi: 10.1016/0016-6480(83)90047-3.
A hypophyseal pars distalis from an 11-day-old chick embryonic donor was implanted in the extraembryonic coelom of a 3-day-old recipient in order to evaluate the reactions of the thyroid of the host embryo and thus the functional capabilities of the grafted pituitary related to the thyroid. The graft did not modify the general growth of the embryo, but strongly influenced thyroidal development. The volume, colloid content, and radioiodide uptake of the thyroid gland were significantly increased, from Day 10 of incubation, compared with controls, as was the development of cytological structures, studied with the electron microscope. However, all these characteristics progressively returned to normal values between Days 14 and 17, in spite of the presence of this additional hypophysis. The grafted hypophysis thus acted autonomously during a first period resulting in increased stimulation of the thyroid. However, from Day 14, the influence of the graft decreased progressively and disappeared after Day 16. This signified the loss of its autonomy, and the mechanism of this loss, particularly the possible role of the hypothalamus, is discussed.
将11日龄鸡胚胎供体的垂体远侧部植入3日龄受体的胚外体腔，以评估宿主胚胎甲状腺的反应，从而评估移植垂体与甲状腺相关的功能能力。移植并未改变胚胎的总体生长，但对甲状腺发育有强烈影响。与对照组相比，从孵化第10天起，甲状腺的体积、胶体含量和放射性碘摄取显著增加，用电子显微镜研究的细胞学结构发育也是如此。然而，尽管存在这个额外的垂体，所有这些特征在第14天至17天之间逐渐恢复到正常水平。因此，移植的垂体在第一阶段自主发挥作用，导致对甲状腺的刺激增加。然而，从第14天起，移植的影响逐渐减弱，并在第16天后消失。这意味着其自主性的丧失，并讨论了这种丧失的机制，特别是下丘脑可能发挥的作用。
