Wakushima T, Kishimoto Y, Hirayama C
Hepatogastroenterology. 1983 Aug;30(4):137-9.
The disappearance of intravenously administered dehydrocholate was studied in 13 healthy subjects and 23 patients with chronic liver disease. Serum dehydrocholate was determined by the enzymatic method using 3 alpha-hydroxysteroid dehydrogenase. Following the loading dose of dehydrocholate, serum dehydrocholate and 3 alpha-hydroxy bile acid were assayed at five minute intervals for 15 minutes. During this 15 minute period, dehydrocholate decreased and 3 alpha-hydroxy bile acid increased. The disappearance of the dehydrocholate was delayed in patients with chronic liver disease, and the 5-minute retention value was significantly high in cirrhosis patients.
在13名健康受试者和23名慢性肝病患者中研究了静脉注射脱氢胆酸盐后的消失情况。血清脱氢胆酸盐采用3α-羟基类固醇脱氢酶的酶法测定。给予脱氢胆酸盐负荷剂量后，每隔5分钟测定血清脱氢胆酸盐和3α-羟基胆汁酸，共测定15分钟。在这15分钟内，脱氢胆酸盐减少，3α-羟基胆汁酸增加。慢性肝病患者中脱氢胆酸盐的消失延迟，肝硬化患者的5分钟潴留值显著升高。
