Nichols W W, Cristofalo V J, Toji L H, Greene A E, Aronson M M, Dwight S, Charpentier R, Hoffman E
In Vitro. 1983 Oct;19(10):797-804. doi: 10.1007/BF02618099.
A human diploid fibroblast cell line has been established from the lung tissue of a male fetus. This has been characterized and frozen away in large quantity. A smaller quantity of fibroblastlike cells from skin has also been established, partially characterized, and placed in frozen storage from the same fetus. This project is in support of the National Institute on Aging research in general cell biology. The present lines designated IMR-91 lung and IMR-91 skin complement the previous human diploid fibroblast culture (IMR-90) established from a female fetus. The lack of random inactivation of one of the two X chromosomes in the present male line reduces the genetic heterogeneity inherent in the female line.
一种人类二倍体成纤维细胞系已从一名男性胎儿的肺组织中建立。该细胞系已被鉴定并大量冻存。同时，也从同一胎儿的皮肤中建立了少量成纤维样细胞，进行了部分鉴定，并置于冻存状态。该项目总体上是为美国国立衰老研究所的细胞生物学研究提供支持。目前命名为IMR - 91肺和IMR - 91皮肤的细胞系补充了之前从一名女性胎儿建立的人类二倍体成纤维细胞培养物（IMR - 90）。当前男性细胞系中两条X染色体之一缺乏随机失活，降低了女性细胞系中固有的遗传异质性。
