Tsao C S, Salimi S L
Int J Vitam Nutr Res. 1983;53(3):258-64.
Large quantities of ascorbic acid or erythorbic acid were administered to Swiss mice over a period of seven months. Urinary ascorbic acid and erythorbic acid were determined two weeks before termination of the experiment. At the end of the experiment, ascorbic acid and erythorbic acid contents in plasma, liver and brain tissues were measured. In the ascorbic acid-treated mice, there was a marked elevation in plasma and urine ascorbate levels, and there was a 38% increase of ascorbate level in the liver but there was no substantial increase in ascorbate levels in the four brain regions studied, namely the cerebrum, cerebellum, medulla and brain stem, upon large intake of ascorbic acid. In the erythorbic acid-treated mice, erythorbic acid is well absorbed by the gastrointestinal tract, enters the blood stream, and is rapidly excreted in the urine. The results show that erythorbic acid is able to replace 45% of ascorbic acid in the liver and 28-39% of ascorbic acid in the brain tissues. Although erythorbic acid appears in the blood at significantly high level, it does not lower blood ascorbate levels.
在七个月的时间里，给瑞士小鼠大量投喂抗坏血酸或异抗坏血酸。在实验结束前两周测定小鼠尿液中的抗坏血酸和异抗坏血酸含量。实验结束时，测量血浆、肝脏和脑组织中的抗坏血酸和异抗坏血酸含量。在投喂抗坏血酸的小鼠中，血浆和尿液中的抗坏血酸盐水平显著升高，肝脏中的抗坏血酸盐水平增加了38%，但在研究的四个脑区（即大脑、小脑、延髓和脑干）中，大量摄入抗坏血酸后，抗坏血酸盐水平没有显著增加。在投喂异抗坏血酸的小鼠中，异抗坏血酸被胃肠道很好地吸收，进入血流，并迅速从尿液中排出。结果表明，异抗坏血酸能够替代肝脏中45%的抗坏血酸以及脑组织中28%-39%的抗坏血酸。尽管异抗坏血酸在血液中的含量显著升高，但它不会降低血液中的抗坏血酸盐水平。
