Sauberlich H E, Tamura T, Craig C B, Freeberg L E, Liu T
Department of Nutrition Sciences, University of Alabama at Birmingham 35294-3360, USA.
Am J Clin Nutr. 1996 Sep;64(3):336-46. doi: 10.1093/ajcn/64.3.336.
Erythorbic acid, an epimer of L-ascorbic acid, is used in the United States as a food additive. Studies were conducted to determine whether the ingestion of erythorbic acid in the diet had any beneficial or adverse effects on the human requirement for vitamin C. Young women were fed diets that contained controlled amounts of erythorbic acid and ascorbic acid. In pharmacokinetic evaluations, erythorbic acid and ascorbic acid were rapidly absorbed with little interaction. Erythorbic acid cleared from the body more rapidly than ascorbic acid. Some subjects received diets deficient in vitamin C for periods < or = 30 d. Increasing intakes of erythorbic acid or prolonged intakes of < or = 1 g erythorbic acid/d did not indicate any interactions with ascorbic acid. Consumption of erythorbic acid resulted in the presence of erythorbic acid in mononuclear leukocytes. Ascorbic acid concentrations in these cells were not affected by the presence of erythorbic acid. Erythorbic acid disappeared quickly from these cells with cessation of erythorbic acid supplements. Prolonged ingestion of erythrobic acid by young women neither antagonized nor spared their vitamin C status.
异抗坏血酸是L-抗坏血酸的差向异构体，在美国用作食品添加剂。开展了多项研究，以确定饮食中摄入异抗坏血酸对人体维生素C需求是否有任何有益或不良影响。给年轻女性喂食含有受控量异抗坏血酸和抗坏血酸的饮食。在药代动力学评估中，异抗坏血酸和抗坏血酸吸收迅速，几乎没有相互作用。异抗坏血酸从体内清除的速度比抗坏血酸更快。一些受试者摄入维生素C缺乏的饮食达30天或更短时间。增加异抗坏血酸摄入量或每天摄入1克或更少的异抗坏血酸并不表明与抗坏血酸有任何相互作用。摄入异抗坏血酸导致单核白细胞中出现异抗坏血酸。这些细胞中的抗坏血酸浓度不受异抗坏血酸存在的影响。停止补充异抗坏血酸后，异抗坏血酸迅速从这些细胞中消失。年轻女性长期摄入异抗坏血酸既不拮抗也不节省她们的维生素C状态。
