Wheldon G H, Bhatt A, Keller P, Hummler H
Int J Vitam Nutr Res. 1983;53(3):287-96.
Rats were fed vitamin E at various dietary concentrations providing dosages of up to 2000 mg/kg bodyweight/day for 104 weeks. Vitamin K supplementation suppressed the induced hypoprothrombinaemia. Growth rate and survival were unaltered by treatment, and, apart from a trend towards fewer mammary tumours in females, the tumour profile was unaffected. Changes in serum liver enzyme activity and in the appearance of the hepatic macrophages suggested a limited hepatic response to vitamin E overload.
给大鼠喂食不同膳食浓度的维生素E，提供高达2000毫克/千克体重/天的剂量，持续104周。补充维生素K可抑制诱导的低凝血酶原血症。生长速率和存活率不受治疗影响，除了雌性乳腺肿瘤有减少的趋势外，肿瘤谱未受影响。血清肝酶活性的变化和肝巨噬细胞的外观表明肝脏对维生素E过载的反应有限。
