Heine U I, Krueger G R, Karpinski A, Munoz E, Krueger M B
J Cancer Res Clin Oncol. 1983;106(2):102-11. doi: 10.1007/BF00395387.
This report describes two types of reticular epithelial cell in the thymic cortex of the BALB/c mouse, an immature and a mature form. During early stages of lymphoma development, i.e., 2-6 weeks postinfection (p.i.) with Moloney leukemia virus (M-MuLV), activation of the epithelial cells is observed. Although the percentage of these cells in the total cell population of the thymic cortex remains constant during that time, the number of mature epithelial cells is significantly increased in infected animals. Subsequently, about 6 weeks p.i., the number of immature epithelial cells starts to increase, whereas the number of mature reticular epithelial cells declines and the appearance of the mature epithelial cells changes drastically. The results of light and electron microscopic studies indicate degeneration of the mature reticular epithelial cells at the onset of lymphoma development at a time when the first deficiencies in the immunologic competence of the reticular epithelial cells are apparent.
本报告描述了BALB/c小鼠胸腺皮质中两种类型的网状上皮细胞，即未成熟型和成熟型。在淋巴瘤发展的早期阶段，即感染莫洛尼白血病病毒（M-MuLV）后2-6周，可观察到上皮细胞的激活。尽管在此期间这些细胞在胸腺皮质总细胞群体中的百分比保持恒定，但感染动物中成熟上皮细胞的数量显著增加。随后，感染后约6周，未成熟上皮细胞的数量开始增加，而成熟网状上皮细胞的数量下降，并且成熟上皮细胞的外观发生了巨大变化。光镜和电镜研究结果表明，在淋巴瘤发展开始时，成熟网状上皮细胞发生退化，此时网状上皮细胞的免疫能力首次出现缺陷。
