莫洛尼病毒诱导的淋巴瘤发生过程中与胸腺上皮缺陷相关的胸腺前淋巴细胞分化阻滞。
Differentiation block of prethymic lymphocytes during Moloney-virus-induced lymphoma development associated with a thymic epithelial defect.
作者信息
Krueger G R, Karpinski A, Heine U I, Koch B
出版信息
J Cancer Res Clin Oncol. 1983;106(2):153-7. doi: 10.1007/BF00395395.
Previous cytokinetic studies in Moloney-virus (M-MuLV)-induced lymphomas of BALB/c mice showed an intrathymic maturation block of prethymic lymphocytes derived from hematopoietic tissues. Thymus-cell cultures during the latent period of lymphoma development showed a proportion of nonlymphoid cells (NLC) from uninfected mice of 0.1% (3 days) to 0.002% (20 days), rising in infected mice to 1-2% after 5 weeks. Concomitantly, thymic epithelial cells exhibit progressive degenerative changes in vivo in infected mice with virus replication and in vitro a marked cellular polymorphism with nuclear atypia becomes overt. Immunofluorescence studies of thymopoietin II and serum thymus factor in epithelial cells indicate a marked decrease of these hormones in the epithelial cells from infected mice. These results suggest a functional defect of virus-infected thymic epithelial cells which causes a progressive accumulation of nondifferentiating T-cell precursors.
先前对莫洛尼病毒（M-MuLV）诱导的BALB/c小鼠淋巴瘤进行的细胞动力学研究表明，源自造血组织的胸腺前淋巴细胞在胸腺内成熟受阻。在淋巴瘤发展的潜伏期，胸腺细胞培养显示，未感染小鼠的非淋巴细胞（NLC）比例为0.1%（3天）至0.002%（20天），在感染小鼠中，5周后该比例升至1%-2%。与此同时，在病毒复制的感染小鼠体内，胸腺上皮细胞呈现进行性退行性变化，在体外，明显的细胞多形性伴核异型性变得明显。上皮细胞中胸腺生成素II和血清胸腺因子的免疫荧光研究表明，感染小鼠上皮细胞中这些激素明显减少。这些结果表明，病毒感染的胸腺上皮细胞存在功能缺陷，导致未分化T细胞前体逐渐积累。
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