Nelson J P, McCarley R W, Hobson J A
J Neurophysiol. 1983 Oct;50(4):784-97. doi: 10.1152/jn.1983.50.4.784.
Pontogeniculooccipital (PGO) waves appeared almost simultaneously in both lateral geniculate nuclei (LGB), but in each case on had a larger amplitude and preceded the other by a few milliseconds. The larger, earlier wave is called the primary wave. Primary waves were found to appear with equal frequency in each LGB. During rapid eye movement sleep (REM sleep), LGB primary waves were ipsilateral to the direction of rapid eye movements. During REM sleep a group of cat midbrain neurons, which we call PGO burst cells, fired in stereotyped bursts at fixed latencies before ipsilateral primary waves, but they almost never fired bursts when the primary waves were contralateral. PGO burst neuron discharge also correlated with the direction of rapid eye movements during REM sleep. In wakefulness, PGO burst cells fired single spikes, not bursts, which had some correlation with LGB waves when averaged by computer. The results suggest that PGO burst cells are output elements in the PGO wave-generation system ad that PGO waves convey eye movement information to the sensory visual system in REM sleep. They also may have a role in the production of saccade-related waves in the visual system during wakefulness.
脑桥-膝状体-枕叶(PGO)波几乎同时出现在两侧外侧膝状体(LGB)中,但每种情况下,其中一个波幅更大,且比另一个波提前几毫秒出现。较大、较早出现的波称为主波。研究发现主波在每个外侧膝状体中出现的频率相同。在快速眼动睡眠(REM睡眠)期间,外侧膝状体主波与快速眼动的方向同侧。在REM睡眠期间,一组猫中脑神经元,我们称之为PGO爆发细胞,在同侧主波之前以固定潜伏期进行刻板爆发式放电,但当主波为对侧时,它们几乎从不爆发放电。PGO爆发神经元放电也与REM睡眠期间快速眼动的方向相关。在清醒状态下,PGO爆发细胞发放单个尖峰,而非爆发式放电,经计算机平均后,这些单个尖峰与外侧膝状体波有一定相关性。结果表明,PGO爆发细胞是PGO波产生系统中的输出元件,并且PGO波在REM睡眠期间将眼动信息传递给视觉感觉系统。它们在清醒状态下视觉系统中与扫视相关的波的产生中可能也起作用。