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莫洛尼鼠白血病病毒的低分子量RNA：RNA指导的DNA合成引物的鉴定

Low-molecular-weight RNAs of Moloney murine leukemia virus: identification of the primer for RNA-directed DNA synthesis.

作者信息

Peters G, Harada F, Dahlberg J E, Panet A, Haseltine W A, Baltimore D

出版信息

J Virol. 1977 Mar;21(3):1031-41. doi: 10.1128/JVI.21.3.1031-1041.1977.

DOI:10.1128/JVI.21.3.1031-1041.1977
PMID:66325
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC515643/
Abstract

The small RNAs of Moloney murine leukemia virus (M-MuLV) were fractionated into at least 15 species by two-dimensional polyacrylamide gel electrophoresis. The pattern of small RNAs is significantly different from that of Rous sarcoma virus. A subset of the virion small RNAs is associated with the genome RNA in the 70S complex. One of the associated molecules, a cellular tRNA, is tightly bound to the genome RNA and serves as the major primer for M-MuLV RNA-directed DNA synthesis in vitro.

摘要

通过二维聚丙烯酰胺凝胶电泳，莫洛尼鼠白血病病毒（M-MuLV）的小RNA被分离为至少15种。小RNA的模式与劳斯肉瘤病毒的模式显著不同。病毒粒子小RNA的一个子集与70S复合物中的基因组RNA相关联。其中一种相关分子，即一种细胞tRNA，紧密结合于基因组RNA，并在体外作为M-MuLV RNA指导的DNA合成的主要引物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55c/515643/558c61fb58b1/jvirol00207-0222-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55c/515643/aaa9f6b6ff3e/jvirol00207-0215-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55c/515643/ee55e9f90b91/jvirol00207-0216-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55c/515643/d212df3946f5/jvirol00207-0217-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55c/515643/8855aa1f3507/jvirol00207-0220-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55c/515643/a400457e84a6/jvirol00207-0221-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55c/515643/558c61fb58b1/jvirol00207-0222-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55c/515643/aaa9f6b6ff3e/jvirol00207-0215-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55c/515643/ee55e9f90b91/jvirol00207-0216-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55c/515643/d212df3946f5/jvirol00207-0217-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55c/515643/8855aa1f3507/jvirol00207-0220-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55c/515643/a400457e84a6/jvirol00207-0221-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55c/515643/558c61fb58b1/jvirol00207-0222-a.jpg

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Covalent linkage between ribonucleic Acid primer and deoxyribonucleic Acid product of the avian myeloblastosis virus deoxyribonucleic Acid polymerase.禽成髓细胞瘤病毒脱氧核糖核酸聚合酶的核糖核酸引物与脱氧核糖核酸产物之间的共价连接。
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Inability of human immunodeficiency virus type 1 produced in murine cells to selectively incorporate primer formula.在鼠细胞中产生的1型人类免疫缺陷病毒无法选择性地掺入引物配方。
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7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G.7SL RNA介导抗病毒胞苷脱氨酶载脂蛋白B mRNA编辑酶催化多肽样3G（APOBEC3G）的病毒体包装。
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Analysis of the replication of HIV-1 forced to use tRNAMet(i) supports a link between primer selection, translation and encapsidation.对被迫使用甲硫氨酸起始tRNA（tRNAMet(i)）的HIV-1复制的分析支持了引物选择、翻译和衣壳化之间的联系。
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tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes.转运RNA促进HIV-1细胞内逆转录复合物的核输入。
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一种用于放射性核苷酸的二维分级分离程序。
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Small RNAs of Rous sarcoma virus: characterization by two-dimensional polyacrylamide gel electrophoresis and fingerprint analysis.劳氏肉瘤病毒的小RNA：通过二维聚丙烯酰胺凝胶电泳和指纹分析进行表征
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Characterization of the low-molecular-weight RNAs associated with the 70S RNA of Rous sarcoma virus.与劳氏肉瘤病毒70S RNA相关的低分子量RNA的特性分析。
J Virol. 1973 Aug;12(2):334-42. doi: 10.1128/JVI.12.2.334-342.1973.