Als A V, Serur J R, LaRaia P J, Miner N C, Paulin S
Radiology. 1978 Aug;128(2):499-501. doi: 10.1148/128.2.499.
Sodium meglumine calcium metrizoate was injected into isolated blood-perfused canine hearts to evaluate the effect of contrast agents containing calcium on normal and ischemic myocardium. Under normal perfusion pressure and mild ischemia, this contrast agent produced a positive inotropic effect, but during profound ischemia, this positive effect was followed by a period of myocardial depression. These findings indicate that the addition of an inotropic agent to contrast medium can produce a paradoxical depressant effect which can be deleterious to the ischemic myocardium.
将葡甲胺钙泛影酸盐注入离体血液灌注的犬心脏，以评估含钙造影剂对正常心肌和缺血心肌的影响。在正常灌注压力和轻度缺血情况下，这种造影剂产生正性肌力作用，但在深度缺血时，这种正性作用之后会出现一段时间的心肌抑制。这些发现表明，在造影剂中添加正性肌力药物可产生矛盾的抑制作用，这对缺血心肌可能有害。
