Green C E, Higgins C B, Kelley M J, Newell J D, Schmidt W S, Haigler F
Cardiovasc Intervent Radiol. 1981;4(2):110-6. doi: 10.1007/BF02552389.
The effects of intracoronary administration of contrast materials on regional and global left ventricular (LV) function were assessed in anesthetized dogs with segmental myocardial ischemia produced by critical stenosis of the circumflex coronary artery. Effects caused by sodium meglumine diatrizoate (R76), sodium meglumine calcium metrizoate (ISO), and metrizamide were evaluated. In the nonischemic state R76 produced an early (0-10 seconds) decrease in LV contractility followed by a late (10-20 seconds) positive inotropic effect. In the presence of regional ischemia there was prolongation of the negative inotropic effect. ISO produced only positive inotropic effects without significant differences between responses in the nonischemic and ischemic states. Metrizamide produced almost no alterations in LV function.
在通过左旋冠状动脉严重狭窄产生节段性心肌缺血的麻醉犬中，评估了冠状动脉内注射造影剂对局部和整体左心室（LV）功能的影响。评估了泛影葡胺钠（R76）、葡甲胺钙泛影酸盐（ISO）和甲泛葡胺的影响。在非缺血状态下，R76使左心室收缩力早期（0 - 10秒）下降，随后晚期（10 - 20秒）出现正性肌力作用。在存在局部缺血的情况下，负性肌力作用延长。ISO仅产生正性肌力作用，在非缺血和缺血状态下的反应之间无显著差异。甲泛葡胺对左心室功能几乎无改变。
