Donker D N, Reits D, Storm van Leeuwen W, Van Sprang F J, Wadman S K
Rev Electroencephalogr Neurophysiol Clin. 1978 Jan-Mar;8(1):55-60. doi: 10.1016/s0370-4475(78)80119-1.
In 6 patients with PKU, being on a low phenylalanine diet, the effect of reintroduction of phenylalanine on the E.E.G. was studied. The children, therefore, received daily loads of 100 or 150 mg phenylalanine/Kg bodyweight, equally divided over the meals. Computerized spectral analysis of the E.E.G's was performed during and after the loading tests. This made quantification possible of the following E.E.G. changes: 1) the increase of activities in the theta frequency band (4-8 Hz); 2) the frequency change of the alpha rhythm; 3) the change of the degree of synchrony between identical frequencies occurring in different derivations. A linear relation was found between these quantified E.E.G. parameters and the phenylalanine blood-level. After stopping the loading test E.E.G. abnormalities reversed suggesting that they could be considered as a measure for the degree of intoxication caused by the phenylalanine and/or its metabolites. It is suggested that the E.E.G. data may be useful parameters for alleviation or termination of the diet.
对6名接受低苯丙氨酸饮食的苯丙酮尿症患者，研究了重新引入苯丙氨酸对脑电图的影响。因此，这些儿童每天摄入100或150毫克/千克体重的苯丙氨酸，每餐平均分配。在负荷试验期间及之后对脑电图进行计算机频谱分析。这使得对以下脑电图变化进行量化成为可能：1）θ频段（4-8赫兹）活动增加；2）α节律的频率变化；3）不同导联中相同频率之间同步程度的变化。发现这些量化的脑电图参数与血液苯丙氨酸水平之间存在线性关系。停止负荷试验后，脑电图异常逆转，这表明它们可被视为苯丙氨酸和/或其代谢产物中毒程度的一种度量。建议脑电图数据可能是减轻或终止饮食的有用参数。
