Donker D N, Reits D, Van Sprang F J, van Leeuwen W S, Wadman S K
Electroencephalogr Clin Neurophysiol. 1979 Feb;46(2):205-13. doi: 10.1016/0013-4694(79)90070-1.
The effect on the EEG of the reintroduction of phenylalanine in the diet of 6 patients with PKU on treatment was studied. Patients received daily loads of 100 or 150 mg L-phenylalanine/kg, equally divided over the meals, and computerized spectral EEG analysis was performed. The following EEG changes were seen: (1) occurrence of activity in the low frequency band (2--5 c/sec), (2) change of frequency of dominant rhythms; (3) change in the degree of synchrony between identical frequencies, occurring in different derivations. EEG changes increased quantitatively parallel to increasing blood phenylalanine and reversed after stopping the phenylalanine administration, suggesting that the EEG abnormalities are a measure for the degree of intoxication caused by phenylalanine or its metabolites. It is suggested that the EEG data may be useful deciding to terminate the diet in PKU.
研究了在6名接受治疗的苯丙酮尿症（PKU）患者的饮食中重新引入苯丙氨酸对脑电图（EEG）的影响。患者每日摄入100或150毫克L-苯丙氨酸/千克，均匀分配到每餐中，并进行了计算机化频谱脑电图分析。观察到以下脑电图变化：（1）低频带（2-5次/秒）活动的出现；（2）主导节律频率的变化；（3）不同导联中相同频率之间同步程度的变化。脑电图变化在数量上随着血苯丙氨酸水平的升高而平行增加，在停止给予苯丙氨酸后逆转，这表明脑电图异常是苯丙氨酸或其代谢产物所致中毒程度的一种衡量指标。有人提出，脑电图数据可能有助于决定PKU患者饮食的终止。
