Gianutsos G, Carlson G M, Godfrey J G
Pharmacol Biochem Behav. 1983 Aug;19(2):263-8. doi: 10.1016/0091-3057(83)90050-3.
The increase in motor activity produced in mice by phenylethylamine (PEA), L-DOPA and amphetamine was evaluated after selective inhibition of MAO Type A (by clorgyline) or Type B (by low doses of pargyline). PEA-induced motor stimulation was intensified in the presence of MAO-B inhibition, but not when MAO-A was inhibited. This was paralleled by higher concentrations of brain and plasma PEA (after injection) in mice in which there was inhibition of MAO-B compared with control or MAO-A inhibition. Conversely, L-DOPA produced significant stimulation only when MAO-A was inhibited. The clorgyline pretreatment resulted in larger increases in brain dopamine concentrations (in the striatum, olfactory tubercles and in the area containing the substantia nigra) than did MAO-B inhibition. This effect occurred both in mice receiving L-DOPA + inhibitor and in mice receiving the inhibitor alone. Amphetamine-induced stimulation was increased following the inhibition of either form of MAO, and this was not the result of changes in the distribution or metabolism of amphetamine. These results support the concept that MAO-A and MAO-B deaminate different substrates in the rodent CNS and that amphetamine may utilize either dopamine or PEA in producing its stimulant effects.
在分别选择性抑制A型单胺氧化酶（通过氯吉兰）或B型单胺氧化酶（通过低剂量的帕吉林）后，评估了苯乙胺（PEA）、左旋多巴和苯丙胺对小鼠运动活性的增强作用。在存在单胺氧化酶B抑制的情况下，PEA诱导的运动刺激增强，但单胺氧化酶A被抑制时则不然。与对照或单胺氧化酶A抑制的小鼠相比，单胺氧化酶B被抑制的小鼠脑和血浆中（注射后）PEA浓度更高，这与上述情况平行。相反，左旋多巴仅在单胺氧化酶A被抑制时产生显著刺激。与单胺氧化酶B抑制相比，氯吉兰预处理导致脑多巴胺浓度（在纹状体、嗅结节和包含黑质的区域）有更大的增加。这种效应在接受左旋多巴 + 抑制剂的小鼠和仅接受抑制剂的小鼠中均出现。在抑制任何一种形式的单胺氧化酶后，苯丙胺诱导的刺激均增加，这并非苯丙胺分布或代谢变化的结果。这些结果支持这样的概念，即单胺氧化酶A和单胺氧化酶B在啮齿动物中枢神经系统中脱氨基不同的底物，并且苯丙胺在产生其刺激作用时可能利用多巴胺或PEA。
