Friedman E, Lerer B, Kuster J
Pharmacol Biochem Behav. 1983 Aug;19(2):309-12. doi: 10.1016/0091-3057(83)90057-6.
Bilateral kainic acid lesions of the ventral globus pallidus produced a significant and selective cortical decrease in choline acetyltransferase activity in the rat brain. When lesioned and control subjects were compared on performance of a step-through passive avoidance task, lesioned rats showed a marked retention deficit 24 hr after the initial training trial. This experimentally-induced memory deficit associated with a cortical cholinergic neuronal loss resembles the deficits in senile dementia of the Alzheimer type and may provide a useful animal model for studying the disease.
腹侧苍白球的双侧海人酸损伤导致大鼠大脑中胆碱乙酰转移酶活性显著且选择性地降低。当对损伤组和对照组在一步通过被动回避任务中的表现进行比较时，损伤组大鼠在初始训练试验后24小时表现出明显的记忆保持缺陷。这种与皮质胆碱能神经元丧失相关的实验性诱导记忆缺陷类似于阿尔茨海默型老年痴呆症的缺陷，可能为研究该疾病提供一个有用的动物模型。
