Oegema T R, Bradford D S, Cooper K M, Hunter R E
Spine (Phila Pa 1976). 1983 May-Jun;8(4):378-84. doi: 10.1097/00007632-198305000-00007.
Six levels of anulus and nucleus were obtained from each of three spines: one with idiopathic scoliosis, one with cerebral palsy, and one age-matched control. Proteoglycans from all spines had the same extractability and distribution in the associative and dissociative cesium chloride density gradients. In all cases, the anulus differed from the nucleus samples in terms of all the parameters studied. There was no difference between the cerebral palsy and idiopathic scoliotic values. However, they both differed from the control values, having significantly higher levels of aggregate and larger nonaggregating monomers, but no significant differences in proteoglycan monomer chemistry. Results indicate that idiopathic scoliosis may not be the result of a biochemical alteration in proteoglycan but that curvature per se may lead to an alteration in the proteoglycan composition, particularly in the nucleus pulposis.
一个患有特发性脊柱侧凸，一个患有脑瘫，还有一个是年龄匹配的对照。所有脊柱中的蛋白聚糖在结合型和游离型氯化铯密度梯度中的可提取性和分布相同。在所有情况下，就所研究的所有参数而言，纤维环与髓核样本不同。脑瘫和特发性脊柱侧凸的值之间没有差异。然而，它们都与对照值不同，聚集物水平显著更高，非聚集单体更大，但蛋白聚糖单体化学性质没有显著差异。结果表明，特发性脊柱侧凸可能不是蛋白聚糖生化改变的结果，而是弯曲本身可能导致蛋白聚糖组成的改变，特别是在髓核中。
