Paulson B A, Becker L D, Way W L
Acta Anaesthesiol Scand. 1983 Oct;27(5):400-2. doi: 10.1111/j.1399-6576.1983.tb01976.x.
The respiratory effects of lorazepam (a 1, 4 benzodiazepine) were studied using a modified Read rebreathing technique in healthy adult males about to undergo elective surgery. Lorazepam 0.05 mg/kg (IV) produced an increase in slope and a shift to the left of the CO2 response curve. These effects were also detectable but of smaller magnitude when the same lorazepam dose (IV) was given with meperidine (IV). End-expiratory CO2 (PeCO2), which was significantly elevated in all drug groups, is not a sensitive indicator of either the time course or the degree of respiratory depression.
采用改良的Read重复呼吸技术，对即将接受择期手术的健康成年男性研究了劳拉西泮（一种1,4 - 苯二氮䓬类药物）的呼吸效应。静脉注射0.05mg/kg劳拉西泮使二氧化碳反应曲线的斜率增加且向左移位。当静脉注射相同剂量的劳拉西泮并同时静脉注射哌替啶时，这些效应也可检测到，但程度较小。所有药物组的呼气末二氧化碳分压（PeCO2）均显著升高，它既不是呼吸抑制时间进程的敏感指标，也不是呼吸抑制程度的敏感指标。
