Ramamurthy S, Steen S N, Winnie A P
Anesth Analg. 1975 May-Jun;54(3):352-6. doi: 10.1213/00000539-197505000-00024.
The intramuscular injection of meperidine (1 mg./kg.) alone causes significant respiratory depression, and doxapram (2 mg./kg.) alone causes significant respiratory stimulation, as evidenced by their ability to shift the carbon dioxide (CO2) response curve to the right and left, respectively. When given together, the mixture of the two drugs does not cause any significant respiratory depression, as indicated by the absence of a significant shift in the CO2 response curve to the right. This mixture has possible clinical usefulness in providing postoperative analgesia without respiratory depression.
单独肌肉注射哌替啶（1毫克/千克）会导致明显的呼吸抑制，而单独注射多沙普仑（2毫克/千克）会导致明显的呼吸兴奋，这分别通过它们使二氧化碳（CO2）反应曲线向右和向左移动的能力得以证明。当两种药物一起使用时，两种药物的混合物不会引起任何明显的呼吸抑制，这由CO2反应曲线向右没有明显移动表明。这种混合物在提供术后镇痛且无呼吸抑制方面可能具有临床实用性。
