Tvedegaard E, Szpirt W, Nielsen M
Acta Pharmacol Toxicol (Copenh). 1983 Sep;53(3):218-22. doi: 10.1111/j.1600-0773.1983.tb01128.x.
The effect of methylprednisolone treatment on the mineral accumulation in the rabbit aorta during chronic renal failure (CRF) was investigated. Groups of rabbits with surgically induced CRF and sham operated controls were treated for 14 weeks with 0.40 mg of methylprednisolone per day and compared to corresponding groups receiving placebo. After sacrifice the thoracic aorta was excised and divided into an inner intima-media and an outer media layer before determination of the content of cholesterol and minerals. The surface area and wet weight of both layers were significantly increased in the CRF groups but methylprednisolone treatment had no effect on these parameters. Neither CRF nor methylprednisolone caused significant changes of the cholesterol content of the intima-media. Methylprednisolone treated CRF rabbits had a significantly decreased mineral content of the intima-media layer compared to CRF rabbits receiving placebo although the treatment caused no significant changes in the serum concentrations of calcium and phosphate. In rabbits with normal renal function a similar effect could not be demonstrated.
研究了甲基强的松龙治疗对慢性肾功能衰竭（CRF）家兔主动脉矿物质蓄积的影响。将手术诱导CRF的家兔组和假手术对照组每天用0.40mg甲基强的松龙治疗14周，并与接受安慰剂的相应组进行比较。处死后，切除胸主动脉，在测定胆固醇和矿物质含量之前，将其分为内膜中层和外膜层。CRF组两层的表面积和湿重均显著增加，但甲基强的松龙治疗对这些参数无影响。CRF和甲基强的松龙均未引起内膜中层胆固醇含量的显著变化。与接受安慰剂的CRF家兔相比，接受甲基强的松龙治疗的CRF家兔内膜中层的矿物质含量显著降低，尽管该治疗未引起血清钙和磷浓度的显著变化。在肾功能正常的家兔中未观察到类似的效果。
