Tvedegaard E, Kamstrup O, Nielsen M, Thomsen H K
Scand J Urol Nephrol. 1983;17(1):119-25. doi: 10.3109/00365598309179794.
The morphological changes in the thoracic aorta induced by chronic renal failure (CRF) were studied in female albino rabbits after seven weeks of CRF. The effect of three and eight months duration of CRF was studied in the proximal part of the abdominal aorta. Renal impairment was induced by electrocoagulation of part of the renal parenchyma of one kidney and subsequent contralateral nephrectomy two weeks later. In the media wavy elastic membranes were the first histological change observed. After long-term CRF necrosis and calcifications with thickening of the vessel wall became frequent and in some rabbits the aorta was changed grossly into a stiff calcified tube. In the intima focal thickenings were found with increasing frequency and severity with increasing duration of the renal insufficiency.
在慢性肾衰竭（CRF）7周后的雌性白化兔中，研究了慢性肾衰竭对胸主动脉形态学的影响。在腹主动脉近端，研究了CRF持续3个月和8个月的影响。通过电凝一侧肾脏部分肾实质，两周后行对侧肾切除术诱导肾功能损害。在中膜，观察到的第一个组织学变化是弹性膜呈波浪状。长期CRF后，血管壁增厚并出现坏死和钙化，在一些兔子中，主动脉明显变成坚硬的钙化管。随着肾功能不全持续时间的增加，内膜局灶性增厚的频率和严重程度也增加。
