Cyclophosphamide effect on changes in rabbit peripheral blood in the development period.

The effect of cyclophosphamide on peripheral blood changes in rabbits to the dose and duration of drug administration and the developmental age of the animal was studied. Cyclophosphamide was administered orally in an aqueous solution. The best tolerated dose was 16 mg/kg of body weight. One such dose decreased transiently the peripheral blood white cell count. The some dose administered during six consecutive days produced blood disturbances the more severe and long-lasting the younger were the animals used in the experiment. With higher cyclophosphamide doses blood changes were associated with signs of development arrest.