The effects of the stimulation of histamine-forming capacity (HFC) and the inhibition of histamine catabolism on tensile strength and collagen content of skin wounds in the rats.

The effects of histamine-forming capacity (HFC) stimulation by 48/80 as well as of histamine catabolism inhibition by aminoguanidine on the tensile strength and collagen production were studied in wounds of rats. 48/80 raised the level of collagen in wounds and increased their tensile strength. Aminoguanidine increased the histamine content of the wounds but markedly lowered the tensile strength and collagen content.