Burrows M E, Johnson P C
Am J Physiol. 1983 Nov;245(5 Pt 1):H796-807. doi: 10.1152/ajpheart.1983.245.5.H796.
These studies were undertaken to determine the importance of metabolic (flow-dependent) and myogenic (pressure-dependent) factors in the response of arterioles to changes in intravascular pressure. The response of 26 arterioles in the isolated cat mesentery to increased venous and arterial pressure was studied by measuring changes of arteriolar diameter, red blood cell velocity, and intravascular pressure. Circumferential wall tension and volume flow in the arterioles were calculated. The fraction of the arteriolar responses to intravascular pressure elevation that could be attributed only to a myogenic response in which wall tension is regulated varied from 20 to 56%, depending on the method of pressure elevation. The largest fraction of the response attributable to a myogenic mechanism (ignoring the contributions of flow) varied from 50 to 93%. The fraction of the responses attributable only to flow dependency varied from 0 to 23%, whereas the largest fraction attributable to this mechanism varied from 18 to 73%, depending on the method of pressure elevation. It is concluded that, in cat mesentery, both metabolic and myogenic mechanisms appear to contribute to local regulation of flow with elevation of intravascular pressure, but other factors cannot be excluded.
开展这些研究是为了确定代谢（流量依赖性）和肌源性（压力依赖性）因素在小动脉对血管内压力变化的反应中的重要性。通过测量小动脉直径、红细胞速度和血管内压力的变化，研究了26条分离的猫肠系膜小动脉对静脉压和动脉压升高的反应。计算了小动脉的周向壁张力和体积流量。小动脉对血管内压力升高的反应中，仅归因于壁张力受调节的肌源性反应的比例在20%至56%之间，这取决于压力升高的方法。归因于肌源性机制（忽略流量的贡献）的反应的最大比例在50%至93%之间。仅归因于流量依赖性的反应比例在0%至23%之间，而归因于该机制的最大比例在18%至73%之间，这取决于压力升高的方法。得出的结论是，在猫肠系膜中，代谢和肌源性机制似乎都有助于血管内压力升高时的局部血流调节，但不能排除其他因素。
