枸橼酸乙胺嗪，一种抗丝虫药，可刺激人粒细胞黏附。
Diethylcarbamazine citrate, an antifilarial drug, stimulates human granulocyte adherence.
作者信息
King C H, Greene B M, Spagnuolo P J
出版信息
Antimicrob Agents Chemother. 1983 Sep;24(3):453-6. doi: 10.1128/AAC.24.3.453.
Abstract
Incubation with diethylcarbamazine citrate caused significant augmentation of human neutrophil and eosinophil adherence to tissue culture plastic. This effect was dose dependent and cell dependent, with eosinophils showing greater sensitivity and a greater adhesive response to the drug than did neutrophils. Eosinophils preincubated with diethylcarbamazine citrate demonstrated decreased adhesive responses to other adherence-augmenting stimuli. Use of Fc-treated plastic augmented diethylcarbamazine citrate-stimulated neutrophil (but not eosinophil) adherence. Direct stimulation of host effector cell adherence may explain, in part, the therapeutic action of diethylcarbamazine citrate in vivo.
摘要
用枸橼酸乙胺嗪孵育可显著增强人中性粒细胞和嗜酸性粒细胞对组织培养塑料的黏附。这种效应呈剂量依赖性和细胞依赖性，嗜酸性粒细胞比中性粒细胞对该药物表现出更高的敏感性和更强的黏附反应。用枸橼酸乙胺嗪预孵育的嗜酸性粒细胞对其他增强黏附的刺激的黏附反应降低。使用经Fc处理的塑料可增强枸橼酸乙胺嗪刺激的中性粒细胞（而非嗜酸性粒细胞）的黏附。宿主效应细胞黏附的直接刺激可能部分解释了枸橼酸乙胺嗪在体内的治疗作用。
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