Sanes J N, Ison J R
Behav Neurosci. 1983 Oct;97(5):833-6. doi: 10.1037//0735-7044.97.5.833.
The supraorbital branch of the right trigeminal nerve was stimulated with trains of electric shocks, 10 in each train, with interpulse intervals of 1, 2, or 5 sec. Electromyographic reflex activity in the palpebral musculature was measured to each pulse in the train. Each response consisted of two components, a fast brief ipsilateral burst (R1) and a slower prolonged bilateral burst (R2). Over the 10-pulse series, the amplitudes of R1 increased in strength (sensitization), whereas the allied R2 amplitudes declined (habituation). Both of these effects were enhanced as the interpulse interval was reduced. A consideration of the anatomical substrate for each reflex component, together with some other data in the literature, suggests that reflex sensitization occurred in the efferent limb of this brain stem reflex while simultaneously habituation occurred in its central link.
用一串电刺激（每串10次）刺激右侧三叉神经眶上支，脉冲间隔为1秒、2秒或5秒。测量每串脉冲刺激时睑部肌肉组织的肌电图反射活动。每次反应包括两个成分，一个快速短暂的同侧爆发（R1）和一个较慢的双侧延长爆发（R2）。在这10次脉冲系列中，R1的振幅强度增加（敏感化），而相关的R2振幅下降（习惯化）。随着脉冲间隔缩短，这两种效应都增强。对每个反射成分的解剖学基础以及文献中的其他一些数据进行考虑后表明，这种脑干反射的传出支发生了反射敏感化，而同时其中枢环节发生了习惯化。
