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黑质多巴胺在苯丙胺诱导的运动活动中的作用。

Role of nigral dopamine in amphetamine-induced locomotor activity.

作者信息

Jackson E A, Kelly P H

出版信息

Brain Res. 1983 Nov 14;278(1-2):366-9. doi: 10.1016/0006-8993(83)90274-3.

DOI:10.1016/0006-8993(83)90274-3
PMID:6640328
Abstract

Dopamine (100 micrograms) injected into the substantia nigra pars reticulata of rats pretreated with the monoamine oxidase inhibitor, pargyline, resulted in a stimulation of locomotor activity. Bilateral injection of the dopamine antagonist haloperidol (5 micrograms) into the substantia nigra pars reticulata resulted in a reduction of the locomotor activity evoked by a low dose of amphetamine (1.25 mg/kg s.c.). These results suggest that the release of dopamine from nigral dendrites is involved in amphetamine-induced locomotor activity.

摘要

将多巴胺(100微克)注射到经单胺氧化酶抑制剂帕吉林预处理的大鼠黑质网状部,会刺激其运动活性。向黑质网状部双侧注射多巴胺拮抗剂氟哌啶醇(5微克),会降低低剂量苯丙胺(1.25毫克/千克,皮下注射)诱发的运动活性。这些结果表明,黑质树突释放多巴胺与苯丙胺诱导的运动活性有关。

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引用本文的文献

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Dichotomy of tyrosine hydroxylase and dopamine regulation between somatodendritic and terminal field areas of nigrostriatal and mesoaccumbens pathways.黑质纹状体和伏隔核中酪氨酸羟化酶和多巴胺调节的躯体树突和末梢区二分法。
PLoS One. 2012;7(1):e29867. doi: 10.1371/journal.pone.0029867. Epub 2012 Jan 5.
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Extrastriatal dopaminergic circuits of the Basal Ganglia.
基底神经节的纹外多巴胺能回路。
Front Neuroanat. 2010 Oct 27;4:139. doi: 10.3389/fnana.2010.00139. eCollection 2010.
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Within-session analysis of amphetamine-elicited rotation behavior reveals differences between young adult and middle-aged F344/BN rats with partial unilateral striatal dopamine depletion.在单次会话分析中,发现部分单侧纹状体多巴胺耗竭的年轻成年和中年 F344/BN 大鼠的安非他命诱发旋转行为存在差异。
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