Davies A O
Can Anaesth Soc J. 1983 Nov;30(6):603-6. doi: 10.1007/BF03015230.
In a prospective, double-blind placebo controlled trial, the effect of oral diazepam premedication on post-succinylcholine fasciculations and myalgia was studied. Forty patients undergoing septoplasty procedures received orally identical capsules containing either 10 mg of diazepam or a placebo 90 minutes preoperatively. A standardized anaesthetic regimen included induction with 5 mg X kg-1 of thiopental and 1 mg X kg-1 of succinylcholine. The diazepam and control groups did not differ significantly in extent of fasciculations or ease of intubation. However, only 15 per cent of the diazepam premedicated patients had myalgias postoperatively compared to 50 per cent of the control patients, a statistically significant difference (p = 0.04).
在一项前瞻性、双盲、安慰剂对照试验中，研究了口服地西泮进行术前用药对琥珀酰胆碱后肌束震颤和肌痛的影响。40例接受鼻中隔成形术的患者在术前90分钟口服相同的胶囊，其中包含10毫克地西泮或安慰剂。标准化麻醉方案包括用5毫克/千克硫喷妥钠和1毫克/千克琥珀酰胆碱诱导麻醉。地西泮组和对照组在肌束震颤程度或插管难易程度上无显著差异。然而，地西泮术前用药的患者术后仅有15%出现肌痛，而对照组患者为50%，差异有统计学意义（p = 0.04）。
