静脉注射三种苯二氮䓬类药物（地西泮、劳拉西泮和氟硝西泮）后的后遗症。
Sequelae after the intravenous injection of three benzodiazepines--diazepam, lorazepam, and flunitrazepam.
作者信息
Hegarty J E, Dundee J W
出版信息
Br Med J. 1977 Nov 26;2(6099):1384-5. doi: 10.1136/bmj.2.6099.1384.
Abstract
The occurrence of thrombosis and phlebitis after intravenous injection of 10 mg diazepam, 4 mg lorazepam, or 1-2 mg flunitrazepam was studied on the second or third and the seventh to 10th days. A significantly higher incidence occurred with all drugs on days 7 to 10 than on days 2 and 3. Painless thrombosis occurred much more often with diazepam than with the other two benzodiazepines. Its incidence was greater in small hand or arm veins than in large antecubital vessels. Lorazepam and flunitrazepam therefore have clear advantages over diazepam.
摘要
在静脉注射10毫克地西泮、4毫克劳拉西泮或1 - 2毫克氟硝西泮后的第二天或第三天以及第七至第十天，对血栓形成和静脉炎的发生情况进行了研究。在第7至10天，所有药物引发的发生率显著高于第2天和第3天。地西泮引发无痛性血栓形成的情况比其他两种苯二氮䓬类药物更为常见。其发生率在手部或手臂的小静脉中比在前臂肘窝的大血管中更高。因此，劳拉西泮和氟硝西泮相对于地西泮具有明显优势。
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