[硝西泮代谢对其给药方法及实验动物种类的依赖性]
[Dependence of nitrazepam metabolism on the method of its administration and species of experimental animals].
作者信息
Golovenko N Ia, Bogatskii A V, Karaseva T L
出版信息
Ukr Biokhim Zh (1978). 1978 May-Jun;50(3):302-6.
PMID:664041
Abstract
Intraperitoneal, intravenous and peroral administration of nitrasepam has no effect on its transformation and distribution in the liver tissues, blood and brain of mice. Depending on the products of nitrasepam transformation formed in the animal liver, the enzymic systems providing such transformations have species peculiarities: the rat liver tissues contain nitroreductase, N-acetyl-transferase and desacetylase. And the mice tissues contain only nitroreductase and desacetylase.
摘要
腹腔内、静脉内和口服给予硝西泮对其在小鼠肝脏组织、血液和大脑中的转化及分布没有影响。根据动物肝脏中形成的硝西泮转化产物，提供这种转化的酶系统具有种属特异性：大鼠肝脏组织含有硝基还原酶、N - 乙酰转移酶和脱乙酰酶。而小鼠组织仅含有硝基还原酶和脱乙酰酶。
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