Golovenko N Ia, Bogatskiĭ A V, Orliuk E I, Kurushin A A, Karaseva T L
Biull Eksp Biol Med. 1977 Jul;84(7):53-6.
Nitrasepam is transformed to amino and acetamide derivatives in the rat intestine. Reduction of nitrasepam and its following acetylation in the duodenum and small intestine are catalyzed by the mucosal enzymes. In the cecum and the large intestine these processes are mediated through the action of the microbes and tissue enzymes, whereas in the rectum--through the microbes only.
硝西泮在大鼠肠道中转化为氨基和乙酰胺衍生物。十二指肠和小肠中硝西泮的还原及其随后的乙酰化由黏膜酶催化。在盲肠和大肠中，这些过程是通过微生物和组织酶的作用介导的，而在直肠中——仅通过微生物。
