Sutkovoi D A, Alferov A N, Letov V N
Ukr Biokhim Zh (1978). 1978 May-Jun;50(3):332-5.
The effect of insulin was studied as applied to the inhibited under conditions of adrenalectomy process of oxidative phosphorylation in the rat liver and heart mitochondria. It is established that adrenalectomy does not change oxidative activity of mitochondria but inhibits the process of phosphorylation, which results in the decreased values of the ADP/O coefficient and the respiratory control. Insulin administered to the adrenalectomized rats 3h before the experiments reduces the disturbed oxidative phosphorylation in mitochondria of the liver and heart by intensifying the degree of ADP phosphorylation.
研究了胰岛素对大鼠肝脏和心脏线粒体在肾上腺切除术后氧化磷酸化过程受抑制情况下的作用。结果表明，肾上腺切除术不会改变线粒体的氧化活性，但会抑制磷酸化过程，这导致ADP/O系数值和呼吸控制降低。在实验前3小时给肾上腺切除的大鼠注射胰岛素，可通过增强ADP磷酸化程度来减轻肝脏和心脏线粒体中受干扰的氧化磷酸化。
