Milne F J, Sharf B, Bell P, Meyers A M
Clin Nephrol. 1983 Oct;20(4):202-7.
Five patients with dialysis encephalopathy were transferred to deionized water; all died after a variable period, 4 of progressive dementia. Six other patients with encephalopathy were started either on deionized or reverse osmosis water as well as desferrioxamine on dialysis. Serial EEG's were performed in this group. In 2 patients the EEG's showed rapid and sustained improvement after the institution of desferrioxamine, whereas there had been no EEG change after 15 and 32 months of reverse osmosis water. In 2 patients there was similar clinical and EEG improvement, related to water change and the institution of desferrioxamine. Two patients died of progressive dementia in spite of both water change and desferrioxamine. Thus, while not a panacea, desferrioxamine has a definitive therapeutic effect on the clinical and EEG manifestations of dialysis encephalopathy, when used in conjunction with deionized or reverse osmosis water.
五名患有透析性脑病的患者改用去离子水；所有患者在一段不同的时间后均死亡，其中4例死于进行性痴呆。另外六名患有脑病的患者在透析时开始使用去离子水或反渗透水以及去铁胺。对该组患者进行了系列脑电图检查。在2例患者中，使用去铁胺后脑电图显示迅速且持续改善，而使用反渗透水15个月和32个月后脑电图无变化。在2例患者中，临床和脑电图有类似改善，与水的更换及使用去铁胺有关。尽管更换了水并使用了去铁胺，仍有2例患者死于进行性痴呆。因此，去铁胺虽不是万灵药，但与去离子水或反渗透水联合使用时，对透析性脑病的临床和脑电图表现具有确切的治疗作用。
