Woodhead A D, Pond V, Dailey K
Exp Gerontol. 1983;18(3):211-21. doi: 10.1016/0531-5565(83)90033-5.
Histological surveys of the kidneys of two poeciliid fishes, the Amazon molly Poecilia formosa and the guppy P. reticulatus, throughout their lifespans showed no regular aging trends. Few kidney lesions were found in the Amazon molly until very late in life, 60 months or more, when obsolescent glomeruli and dilated renal tubules occurred. Guppies showed involutional changes of the renal system earlier, and the lesions became more severe with age, particularly in male fish. Hemopoietic tissue was reduced in amount in older fish of both species. Guppies of a year and older had marked accumulation of melanin in the melanomacrophage centers of the kidney, and the amount present increased with age. By contrast, there was little melanin deposition in mollies until almost the end of the lifespan. Hyaline droplets were consistently seen in the renal tubules of the mollies, but were rare in guppies. The degenerative changes in the kidneys of these two teleosts are similar to those seen in the kidneys of aging mammals. Despite the loss of normal structure in older fish, it seemed unlikely that degeneration of the kidney was directly involved in aging and death.
对两种食蚊鱼，即亚马孙帆鳉（Poecilia formosa）和孔雀鱼（P. reticulatus）的肾脏进行的全生命周期组织学调查显示，没有发现规律性的衰老趋势。在亚马孙帆鳉生命的很晚阶段，即60个月或更晚时，才发现很少的肾脏病变，此时出现了衰老的肾小球和扩张的肾小管。孔雀鱼的肾脏系统较早出现退化性变化，且病变随年龄增长而加重，尤其是雄鱼。两种鱼的老龄个体中造血组织数量均减少。一岁及以上的孔雀鱼在肾脏的黑素巨噬细胞中心有明显的黑色素积累，且积累量随年龄增加。相比之下，直到寿命接近尾声时，帆鳉体内的黑色素沉积都很少。在帆鳉的肾小管中始终能看到透明滴，但在孔雀鱼中很少见。这两种硬骨鱼肾脏的退行性变化与老龄哺乳动物肾脏中的变化相似。尽管老龄鱼的肾脏失去了正常结构，但肾脏退化似乎不太可能直接导致衰老和死亡。
