Almazan G, Pacheco P, Sourkes T L
Exp Brain Res. 1983;50(2-3):321-8. doi: 10.1007/BF00239196.
The increase in activity of adrenocortical ornithine decarboxylase (ODC) elicited by the administration of apomorphine (APM) was studied in rats, four days after transection of the spinal cord or 24 h after various types of brain surgery: transection of the mesencephalon or of the diencephalon, or hypothalamic deafferentation (creation of a "hypothalamic island"). Section of the cord elevated endogenous adrenocortical ODC activity and potentiated the induction of the enzyme by APM. Incomplete sections of the brain at the level of the mesencephalon or diencephalon produced no change in either endogenous or induced ODC activity. In contrast to this, interruption of the mesencephalic-diencephalic connections by complete diencephalic transection produced profound decreases of endogenous ODC and of the response to APM. Deafferentation of the hypothalamus raised endogenous ODC concentrations of the adrenal cortex and potentiated the response to APM. The results strongly suggest that APM acts at the level of the diencephalon (hypothalamus) to increase adrenocortical ODC activity. Diencephalic-mesencephalic connections must be intact for this to occur. Peripheral and extrahypothalamic influences play a modulatory role in this effect.
在大鼠脊髓横断4天后或各类脑部手术后24小时，研究了阿扑吗啡（APM）给药引发的肾上腺皮质鸟氨酸脱羧酶（ODC）活性增加情况：中脑或间脑横断，或下丘脑去传入（创建“下丘脑岛”）。脊髓横断提高了内源性肾上腺皮质ODC活性，并增强了APM对该酶的诱导作用。中脑或间脑水平的脑部不完全横断对内源性或诱导的ODC活性均无影响。与此相反，完全间脑横断中断中脑 - 间脑连接导致内源性ODC以及对APM的反应大幅降低。下丘脑去传入提高了肾上腺皮质的内源性ODC浓度，并增强了对APM的反应。结果强烈表明，APM作用于间脑（下丘脑）水平以增加肾上腺皮质ODC活性。为此，中脑 - 间脑连接必须完整。外周和下丘脑外的影响在这一效应中起调节作用。
