[下丘脑刺激对大鼠心肌中乳酸脱氢酶和苹果酸脱氢酶活性的影响]
[Effect of hypothalamic stimulation on lactate- and malate dehydrogenase activities in rat cardiac muscle].
作者信息
Masiuk A I, Slobodian M M, Marinova L N, Berdyshev G D
出版信息
Fiziol Zh SSSR Im I M Sechenova. 1983 Oct;69(10):1286-92.
PMID:6641978
Abstract
The activity of lactic and malic dehydrogenases was examined in the rat heart after stimulation of the hypothalamus. The activity of LDG and MDG was increased after stimulation of the paraventricular nuclei of the hypothalamus and decreased after stimulation of the ventromedial nuclei. Both effects were abolished by preliminary injection of actinomycin D. This finding suggests an important role of heart cells' genetic apparatus in the neurohormonal regulation of the heart metabolism.
摘要
在下丘脑受到刺激后，对大鼠心脏中的乳酸脱氢酶和苹果酸脱氢酶的活性进行了检测。刺激下丘脑室旁核后，LDG和MDG的活性增加；刺激腹内侧核后，其活性降低。这两种效应均被预先注射放线菌素D所消除。这一发现表明心脏细胞的遗传机制在心脏代谢的神经激素调节中起着重要作用。
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