Barashkova G M, Shvachkin Iu P, Smirnova A P, Shishkina A A, Zavalishina N A
Fiziol Zh SSSR Im I M Sechenova. 1983 Oct;69(10):1327-32.
Alteration of the enkephalin molecule by means of synthesis of peptide with opposite direction of peptide connections between residues of aminoacids (retro--methionin--5--enkephalin) entailed some changes of its action in respect to activity of the stomach secretory cells in dogs. Thus, for instance, the retroanalogue methionin--5--enkephalin proved to be a more efficient activator of gastric secretion induced with pentagastrin.
通过合成氨基酸残基之间肽连接方向相反的肽(逆甲硫氨酸-5-脑啡肽)来改变脑啡肽分子,这使其在对犬胃分泌细胞活性的作用方面发生了一些变化。例如,事实证明,逆类似物甲硫氨酸-5-脑啡肽是一种更有效的由五肽胃泌素诱导的胃液分泌激活剂。