Kowalewski K, Kolodej A
Pharmacology. 1976;14(3):218-26. doi: 10.1159/000136598.
Totally isolated canine stomachs, perfused extracorporeally with homologous blood of living oxygenerator-dogs, were used for the study of gastric secretion. Aminophylline and pentagastrin were infused into the gastric arterial system separately or combined. Aminophylline, infused alone, did not stimulate gastric secretion. However when aminophylline was administered during the infusion of pentagastrin, it significantly augmented the action of this peptide on gastric acid secretion. Aminophylline did not alter myoelectrical and mechanical response to pentagastrin nor did it affect the myoelectrical activity of the nonstimulated stomach. Gastric arterial perfusion pressure and gastric peripheral resistance were reduced during infusion of aminophylline alone or in combination with pentagastrin.
将完全分离的犬胃用活的氧合器犬的同源血液进行体外灌注，用于研究胃液分泌。氨茶碱和五肽胃泌素分别或联合注入胃动脉系统。单独注入氨茶碱不会刺激胃液分泌。然而，当在注入五肽胃泌素期间给予氨茶碱时，它显著增强了该肽对胃酸分泌的作用。氨茶碱不会改变对五肽胃泌素的肌电和机械反应，也不会影响未受刺激胃的肌电活动。单独注入氨茶碱或与五肽胃泌素联合注入时，胃动脉灌注压和胃外周阻力会降低。
