Canković-Darracott S, Braimbridge M V, Williams B T, Bitensky L, Chayen J
J Thorac Cardiovasc Surg. 1977 May;73(5):699-706.
Five different types of myocardial protection were employed in this series of 168 patients undergoing aortic valve replacement. Two methods of assessing myocardial preservation were used: cellular biological estimations and quantitative polarization measurements. Both parameters showed that either of two methods, continuous perfusion at 32 degrees C. with a beating heart or cardioplegic hypothermic arrest, protected the myocardum best. Intermittent perfusion at 30 degrees C. with a fibrillating heart was the worst means of preservation. Our investigations (both clinical and experimental) have also shown that changes in birefringence, indicative of deteriorating myocardial function, are often detectable before parallel cytochemical changes are apparent.
在这组168例接受主动脉瓣置换术的患者中，采用了五种不同类型的心肌保护方法。使用了两种评估心肌保存的方法：细胞生物学评估和定量极化测量。两个参数均显示，两种方法中的任何一种，即32摄氏度持续灌注并保持心脏跳动或心脏停搏低温灌注，对心肌的保护效果最佳。30摄氏度间歇灌注并使心脏颤动是最差的保存方法。我们的研究（包括临床和实验研究）还表明，在平行的细胞化学变化明显之前，通常可以检测到双折射的变化，这表明心肌功能正在恶化。
