Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y
Gan. 1983 Oct;74(5):619-21.
P388 leukemia cells resistant to vincristine contained more calcium in the cells than the parent sensitive line, especially in the form of EGTA-removable (surface-bound) calcium. Although the relationship, if any, between the high cellular calcium of resistant cells and drug-resistant phenotype is not clear, the possible implications of this result for the elucidation of the mechanisms of drug resistance are interesting.
对长春新碱耐药的P388白血病细胞比其亲本敏感株细胞含有更多的钙，尤其是以EGTA可去除（表面结合）钙的形式存在。尽管耐药细胞的高细胞钙与耐药表型之间的关系（如果有的话）尚不清楚，但这一结果对于阐明耐药机制的潜在意义是有趣的。
