Menge M
Fortschr Med. 1983 Oct 20;101(39):1787-91.
Among other diphosphonates here described propane-2,2-diphosphonate displays specific effects on bone-turnover. In contrast to other diphosphonates propane-2,2-diphosphonate inhibits especially different enzymes of growing bone and therefore inhibits formation of bone. The indication for the clinical use follows from that effect: pathologic states with increased bone formation may be treated by application of propane-2,2-diphosphonate.
在本文所述的其他二膦酸盐中，丙烷 - 2,2 - 二膦酸盐对骨转换具有特定作用。与其他二膦酸盐不同，丙烷 - 2,2 - 二膦酸盐特别抑制正在生长的骨骼中的不同酶，因此抑制骨形成。其临床应用的适应症源于该作用：骨形成增加的病理状态可通过应用丙烷 - 2,2 - 二膦酸盐进行治疗。
