Nishimura R A, Fuster V, Burgert S L, Puga F J
Int J Cardiol. 1983 Nov-Dec;4(4):443-54. doi: 10.1016/0167-5273(83)90194-8.
We followed 34 consecutive patients with the postpericardiotomy syndrome for a median of 7 years. In each patient, the syndrome was documented by the occurrence of: (1) a pericardial type of pain or pericardial rub (or both); and (2) fever or an elevated erythrocyte sedimentation rate. The postpericardiotomy syndrome occurred at a median postoperative time of 4 weeks (range, 2 to 52 weeks). The duration of the syndrome was highly variable (range, 2 to 100 days; median, 22 days) and depended primarily on treatment; the median duration of symptoms in 21 patients treated with salicylates alone was only 4 days. Of the 9 patients receiving anticoagulants alone and in whom this treatment was continued, none had clinical evidence of hemopericardium. On follow-up, 7 patients (21%) had an initial recurrence at an interval of 1 to 3 months; 5 of these patients had further recurrences at an interval of 3 to 30 months. This long-term study indicates that the postperiocardiotomy syndrome is a benign but often recurrent clinical entity, presumably related to viral and/or immunologic factors.
我们对34例连续性心脏切开术后综合征患者进行了中位时间为7年的随访。在每例患者中，该综合征通过以下情况得以证实：（1）心包型疼痛或心包摩擦音（或两者兼具）；以及（2）发热或红细胞沉降率升高。心脏切开术后综合征发生的中位术后时间为4周（范围为2至52周）。该综合征的持续时间差异很大（范围为2至100天；中位时间为22天），且主要取决于治疗；仅接受水杨酸盐治疗的21例患者症状的中位持续时间仅为4天。在仅接受抗凝治疗且持续该治疗的9例患者中，无一例有心脏积血的临床证据。随访时，7例患者（21%）在1至3个月的间隔期出现首次复发；其中5例患者在3至30个月的间隔期出现进一步复发。这项长期研究表明，心脏切开术后综合征是一种良性但常复发的临床病症，可能与病毒和/或免疫因素有关。
