Negi A, Marmor M F
Invest Ophthalmol Vis Sci. 1983 Nov;24(11):1475-9.
We studied the role of the retinal pigment epithelium (RPE) in the resorption of different subretinal fluids from under small experimental retinal detachments (blebs) in the rabbit. Damaging the RPE with sodium iodate caused the resorption time, for blebs made with an ionic solution (Hanks'), to decrease from 2-6 hours to only about 30 minutes. Blebs made with sucrose also absorbed much more quickly after iodate. However, blebs made with autologous serum resorbed no faster after iodate. We conclude that iodate destroys the membrane barrier properties of the RPE, allowing subretinal fluid to cross freely according to oncotic pressure. We postulate that in the normal eye, where osmotic fluid movement is low because of the high resistance barrier, the RPE must transport fluid actively to keep the subretinal space dehydrated.
我们研究了视网膜色素上皮（RPE）在兔眼小实验性视网膜脱离（泡状脱离）下方不同视网膜下液吸收过程中的作用。用碘酸钠损伤RPE后，由离子溶液（汉克斯液）形成的泡状脱离的吸收时间从2 - 6小时缩短至仅约30分钟。用蔗糖形成的泡状脱离在碘酸钠处理后吸收也快得多。然而，用自体血清形成的泡状脱离在碘酸钠处理后吸收并没有更快。我们得出结论，碘酸钠破坏了RPE的膜屏障特性，使视网膜下液能根据渗透压自由穿过。我们推测，在正常眼中，由于高阻力屏障导致渗透液移动较少，RPE必须主动转运液体以保持视网膜下间隙脱水。
