Reik T R, Rempel W E, McGrath C J, Addis P B
J Anim Sci. 1983 Oct;57(4):826-31. doi: 10.2527/jas1983.574826x.
One thousand six hundred forty-one Pietrain, 163 Minnesota No. 1 and 158 Pietrain X Minnesota No. 1 crosses and their reciprocals were tested for porcine stress syndrome susceptibility using halothane gas between September 1975 and July 1981. The frequency of reactors in the Pietrain breed was 93.9%. Matings of reactor males to reactor females within the Pietrain breed resulted in 632 reactor and 14 nonreactor offspring. A boar, judged to be nonpenetrant on the basis of the halothane reaction of his parents and littermates, was shown by progeny test to be homozygous for the halothane allele. These data indicate that halothane sensitivity is due to a single autosomal recessive gene with a penetrance of about 98% and a frequency of .98 in this Pietrain herd. No halothane reactors were found in the 163 Minnesota No. 1 pigs tested. Only one Pietrain X Minnesota No. 1 gilt reacted positively to halothane and later, the same gilt produced both positive and negative offspring, indicating that she was most likely heterozygous. Blood group typing of 107 crossbred pigs provided insufficient information to predict accurately the halothane reaction, although some associations were observed between the A and H loci and halothane sensitivity. The time taken by Pietrain pigs to react to halothane was measured and recorded. Analysis of these data showed that progeny of some sires had significantly faster reaction times than others and that reaction time had decreased over the years. These results as well as other data presented here indicate the existence of certain modifier genes that influence halothane reaction.
1975年9月至1981年7月期间，使用氟烷气体对1641头皮特兰猪、163头明尼苏达1号猪以及158头皮特兰×明尼苏达1号杂交猪及其反交后代进行了猪应激综合征易感性测试。皮特兰品种中反应者的频率为93.9%。在皮特兰品种内，反应公猪与反应母猪交配产生了632头反应后代和14头非反应后代。一头公猪，根据其父母和同窝仔猪的氟烷反应判断为非渗透型，但通过后代测试表明其对氟烷等位基因为纯合子。这些数据表明，氟烷敏感性是由一个常染色体隐性基因引起的，该基因的外显率约为98%，在这个皮特兰猪群中的频率为0.98。在测试的163头明尼苏达1号猪中未发现氟烷反应者。只有一头皮特兰×明尼苏达1号小母猪对氟烷呈阳性反应，后来，同一头小母猪产下了阳性和阴性后代，这表明她很可能是杂合子。对107头杂交猪进行血型分型，虽然在A和H位点与氟烷敏感性之间观察到一些关联，但提供的信息不足以准确预测氟烷反应。测量并记录了皮特兰猪对氟烷的反应时间。对这些数据的分析表明，一些公猪的后代反应时间明显比其他公猪的后代快，并且反应时间多年来有所下降。这些结果以及此处呈现的其他数据表明存在某些影响氟烷反应的修饰基因。
