Lerer B, Stanley M, Demetriou S, Gershon S
J Neurochem. 1983 Dec;41(6):1680-3. doi: 10.1111/j.1471-4159.1983.tb00880.x.
Single electroconvulsive shock (ECS) induced no change in [3H]quinuclidinyl benzilate ([3H]QNB) binding to muscarinic cholinergic receptors in rat cortex and hippocampus. ECS administered once daily for 7 days induced a significant reduction in [3H]QNB binding in both brain areas. Concurrent ECS reversed the significant increase in cortical [3H]QNB binding induced by chronic atropine administration. These findings may have relevance to the antidepressant or amnestic effects of electroconvulsive therapy.
单次电惊厥休克（ECS）对大鼠皮层和海马中[3H]喹核醇基苯甲酸酯（[3H]QNB）与毒蕈碱胆碱能受体的结合无影响。每天给予一次ECS，连续7天，可导致这两个脑区中[3H]QNB结合显著减少。同时给予ECS可逆转慢性给予阿托品所诱导的皮层[3H]QNB结合的显著增加。这些发现可能与电惊厥治疗的抗抑郁或遗忘作用相关。
