Mann J J, Stanley M, Kaplan R D, Sweeney J, Neophytides A
J Neurol Neurosurg Psychiatry. 1983 Oct;46(10):905-10. doi: 10.1136/jnnp.46.10.905.
Cerebrospinal fluid levels of homovanillic acid (HVA) in unmedicated patients with Parkinson's disease were 45% of levels in control subjects. Levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and platelet monoamine oxidase activity (MAO) did not differ. Within the Parkinson's disease group platelet MAO B activity correlated with HVA (an MAO B substrate) but not MHPG (an MAO A substrate). A mild global dementia was found that did not correlate with the more severe motor deficit. There was a negative correlation between the motor deficit and HVA levels but not with MHPG. Cognitive functioning correlated positively with platelet MAO, and the ratio of HVA to MHPG levels and negatively with MHPG alone. It is postulated that dopaminergic and noradrenergic activity or the functional balance between these systems may contribute to the observed cognitive dysfunction.
未接受药物治疗的帕金森病患者脑脊液中高香草酸(HVA)水平为对照受试者水平的45%。3-甲氧基-4-羟基苯乙二醇(MHPG)水平和血小板单胺氧化酶活性(MAO)无差异。在帕金森病组中,血小板MAO B活性与HVA(一种MAO B底物)相关,但与MHPG(一种MAO A底物)无关。发现存在轻度的全面性痴呆,且与更严重的运动功能障碍无关。运动功能障碍与HVA水平呈负相关,但与MHPG无关。认知功能与血小板MAO、HVA与MHPG水平的比值呈正相关,与单独的MHPG呈负相关。据推测,多巴胺能和去甲肾上腺素能活性或这些系统之间的功能平衡可能导致了观察到的认知功能障碍。