Howlett R M, Kakulas B A, Fox R A
J Neurol Sci. 1983 Oct;61(2):277-81. doi: 10.1016/0022-510x(83)90011-4.
Using lymphoblastoid cell cultures the response to gamma (gamma)-radiation, was examined in 6 Duchenne muscular dystrophy (DMD) patients; 2 clinically normal males as negative controls, and 2 patients with ataxia telangiectasia (AT) showing sensitivity to ionising radiation as positive controls. In a series of experiments, cell recovery and growth at day 2 post radiation, was determined after 5 separate gamma-irradiation dose levels: 50, 100, 150, 200 and 300 rads. The DMD cell strains showed a radiation dose response that was significantly greater than in cells from 2 normal males, while both DMD and normal cells were significantly less responsive than were AT-sensitive cell strains.
利用淋巴母细胞培养物，对6名杜氏肌营养不良症（DMD）患者、2名临床正常男性作为阴性对照以及2名共济失调毛细血管扩张症（AT）患者（显示对电离辐射敏感作为阳性对照）进行了γ辐射反应检测。在一系列实验中，在5个不同的γ辐射剂量水平（50、100、150、200和300拉德）后，测定了辐射后第2天的细胞恢复和生长情况。DMD细胞株显示出的辐射剂量反应明显大于2名正常男性细胞，而DMD细胞和正常细胞的反应均明显低于AT敏感细胞株。
