Hodge C J, Apkarian A V, Stevens R T, Vogelsang G D, Brown O, Franck J I
J Neurophysiol. 1983 Nov;50(5):1220-35. doi: 10.1152/jn.1983.50.5.1220.
The effect of stimulating the dorsolateral pons (DLP) in the region of locus ceruleus (LC) on lumbar dorsal horn cell responses to innocuous and noxious cutaneous stimuli was assessed and the dependence of these effects on intact pontospinal catecholaminergic systems was tested in chloralose-anesthetized cats. DLP stimulation inhibited the responses of dorsal horn cells to both noxious and innocuous skin stimuli. The inhibitory effect was most prominent when the responses to noxious stimuli were tested. The thresholds for eliciting DLP-spinal inhibition were lowest (less than 30 microA) in the region of LC. The inhibitory effect was found in both ipsilateral and contralateral dorsal horns. The DLP-spinal inhibition was unaltered by depletion of spinal catecholamines brought about by repeated lumbar intrathecal administration of 6-hydroxydopamine or systemic administration of reserpine. We conclude that the DLP-dorsal horn inhibition is not related to a catecholaminergic ceruleospinal system in the cat and that the dependence of pain modulation by catecholamine systems is a reflection of other descending pathways.
在水合氯醛麻醉的猫中，评估了刺激蓝斑（LC）区域的背外侧脑桥（DLP）对腰髓背角细胞对无害和有害皮肤刺激反应的影响，并测试了这些效应对完整脑桥脊髓儿茶酚胺能系统的依赖性。DLP刺激抑制了背角细胞对有害和无害皮肤刺激的反应。在测试对有害刺激的反应时，抑制作用最为明显。在LC区域，引发DLP-脊髓抑制的阈值最低（小于30微安）。在同侧和对侧背角均发现了抑制作用。通过反复腰段鞘内注射6-羟基多巴胺或全身注射利血平使脊髓儿茶酚胺耗竭后，DLP-脊髓抑制作用未改变。我们得出结论，猫中DLP-背角抑制与儿茶酚胺能蓝斑脊髓系统无关，儿茶酚胺系统对疼痛调制的依赖性反映了其他下行通路。
