Zuber V L
Vopr Med Khim. 1978 Mar-Apr;24(2):163-6.
Effect of acute and chronic forms of hyperphenylalaninemia on intensity of metabolism and content of some phospholipid fractions was studied in brain of growing rats. Acute form of hyperphenylalaninemia caused a decrease in metabolic activity of phospholipids but did not affect their content. In chronic hyperphenylalaninemia more distinct alterations in brain phospholipids metabolism were manifested as a decrease in their content and in their metabolic intensity. The data obtained suggest that brain demyelination developed in chronic hyperphenylalaninemia.
研究了急性和慢性高苯丙氨酸血症对生长中大鼠大脑代谢强度和某些磷脂组分含量的影响。急性高苯丙氨酸血症导致磷脂代谢活性降低，但不影响其含量。在慢性高苯丙氨酸血症中，大脑磷脂代谢出现更明显的改变，表现为其含量和代谢强度降低。所获得的数据表明，慢性高苯丙氨酸血症会导致大脑脱髓鞘。
